The piezoelectric effect was discovered more than 130 years. This course provides a fundamental knowledge of piezoelectric materials from devices to systems. Different perspectives such as from mechanical engineers, electrical engineers and material engineers will also be examined. Smart structures based on piezoelectric materials will serve as an initial platform to examine the pros and cons of distributed and point sensors. The design concept, performance specifications, application knowhow, etc., will be examined for both sensors and actuators. Simple control theories will be briefly introduced to understand the fundamental requirements of sensors within a control loop. Co-located sensors and actuators for flexible structure control and sensor system performance will also be examined. Both theoretical framework and experimental implementations will be discussed. The interface circuitry that can be used to tailor sensor and actuator performance will be discussed. Various application potential of the different scenarios will be used to provide the background, implementation details, and design considerations of the schematics.